The evolution of reproductive self-sacrifice is well understood from kin theory, yet our understanding of how actual genes influence the expression of reproductive altruism is only beginning to take shape. In this study we use microarray meta-data and a co-citation analysis to describe what gene interactions might regulate a worker’s response to ovary suppressing queen pheromone. We reconstruct a total of nine gene networks that vary in size and gene composition, but that are enriched for genes of reproductive function. The networks identify, for the first time, which candidate microarray genes are of functional importance, as evidenced by their degree of connectivity to other genes within each of the inferred networks. Our study identifies single genes of interest related to oogenesis, including eggless, and further implicates multi-gene pathways related to insulin, ecdysteroid, and dopamine signaling as potentially important to reproductive decision making in honey bees. The networks generated here are provisional but do offer a new multi-gene framework for understanding how honey bees regulate personal reproduction within their highly social breeding system.