The world’s largest remaining marsupial carnivore, the Tasmanian devil, is being driven to extinction by the spread of a disease known as the devil facial tumour disease (DFTD). This disease has wiped out over 80% of the devil population since its emergence in 1996. In order to investigate the immunology of the disease and for the development of therapeutic agents against DFTD, a thorough understanding of the devil immune system is required. In 2011 two genome sequences of the Tasmania devil were released. This has provided us with raw data required to study the devil immune system in depth. I have investigated the devil immunome, focusing on cytokines, chemokines and genes of the innate immune system. The majority of these genes are conserved with direct orthologues in humans and opossum, though lineage specific duplications are present in chemokines, interferons and several interleukins. Using re-sequencing data from nine devils I have identified SNPs within devil immune genes. While the polymorphism of devil genes in low, immune genes containing non-synonymous SNPs are present. Maintenance of this variation will be critical for the devil breeding program.